The short version
This comparison changed in late 2025. Microsoft moved AutoGen into maintenance mode and named Microsoft Agent Framework as its successor. AutoGen still works and its ideas remain useful, but it no longer gets new features.
So the practical question is no longer AutoGen or CrewAI. It is CrewAI or Microsoft Agent Framework for new work, and when to move existing AutoGen systems.
Where AutoGen still wins
Conversational multi-agent research. AutoGen made agent-to-agent conversation easy: group chats, critic and writer pairs, and agents that write and run code together. For exploring how agents can collaborate on open-ended problems, its patterns are clear and well documented.
.NET support. AutoGen has Python and .NET packages. CrewAI is Python only. For .NET teams, though, the forward-looking choice is Microsoft Agent Framework, which also supports .NET.
Existing systems. If an AutoGen deployment works and is tested, there is no emergency. Keep it running, pin versions, and schedule a migration with the official guide.
AutoGen Studio. Its low-code interface is still handy for prototyping agent teams before writing code.
Where CrewAI wins
Active development. CrewAI ships regularly and its documentation, examples and integrations keep pace with new model capabilities. That matters for anything you will run for years.
A clear mental model. Agents have a role, goal and backstory. Tasks have owners and expected outputs. Processes run sequentially or under a manager agent. Business stakeholders can read a crew definition and understand it.
Flows for control. CrewAI Flows wrap crews in event-driven state, branching and loops. You keep autonomy where it helps and predictability everywhere else.
Deployment. CrewAI AMP deploys, monitors and scales crews in the cloud or on-premise, with Crew Studio for no-code building.
What we recommend
Do not start new production work on AutoGen. For a Python team building role-based agents, use CrewAI. For a team on .NET or deep in Azure and Microsoft Foundry, use Microsoft Agent Framework. If the process needs explicit state and approvals, also consider LangGraph (CrewAI vs LangGraph).
Many projects need fewer agents than they first assume. A single well-designed agent often beats a crew on cost and reliability. See the cost of a multi-agent system for budgets, or start a conversation about migrating an AutoGen system.