The short version
Microsoft now sells Microsoft 365 Copilot under the name Microsoft Copilot, and Copilot Chat as Microsoft Copilot Chat. This page uses the older name because many buyers still search for it.
These two products answer different questions. Microsoft 365 Copilot asks, “How can AI help inside the apps where your work already happens?” ChatGPT Enterprise asks, “What is the most capable general assistant we can give every employee?”
If your company lives in Outlook, Teams and SharePoint, Copilot’s ability to summarize a meeting you missed, draft a reply from an email thread or pull figures from files you have access to is hard to replicate. If your tools are mixed, or the main need is research, analysis and writing, ChatGPT Enterprise is often the stronger daily assistant.
Where Microsoft 365 Copilot wins
It works where people already are. Copilot appears in Word, Excel, PowerPoint, Outlook and Teams. There is no new app to adopt, and the context of the current document, thread or meeting comes along automatically.
Grounding in Microsoft 365 data. Copilot uses Microsoft Graph to draw on email, chats, documents and meetings the user can access. Questions like “what did we agree with this client last month” can be answered from real records.
Governance in one place. Prompts and responses stay within the Microsoft 365 service boundary under Microsoft’s enterprise data protection, are not used to train the underlying models, and follow your retention and eDiscovery policies. For IT and compliance teams already invested in Microsoft Purview, that is a strong argument.
Agents next to Power Automate. Copilot Studio lets you build custom agents that connect to the same Power Platform tools many Microsoft shops already use. Our Zapier vs Power Automate page covers that side of the stack.
Where ChatGPT Enterprise wins
A stronger standalone assistant. For open-ended research, analysis, writing and image work, ChatGPT is a focused, capable tool that many employees already know.
Works with any stack. Company knowledge connectors reach SharePoint, Google Drive and other apps, so it fits companies on Google Workspace or a mix of systems.
Shareable GPTs and agents. Teams can package instructions, files and tools into custom GPTs or workspace agents and share them without IT building anything.
Enterprise controls. SSO, SCIM, role-based access, a Compliance API, custom retention and data residency options cover most security reviews. Business data is not used for training by default.
What we recommend
Start from where your people spend their day. For a Microsoft 365 company, pilot full Copilot with a group that lives in Outlook and Teams, such as account managers or operations leads, and measure time saved on meetings, email and document drafting. Fix oversharing in SharePoint before you expand. Our AI readiness assessment covers permissions, data and use-case priorities in one pass.
For a mixed or Google-based company, ChatGPT Enterprise is usually the simpler standard. Also compare it with Claude, as covered in Claude Enterprise vs ChatGPT Enterprise.
Either way, licenses alone rarely change how people work. Budget for training and a handful of well-defined use cases per team. Our AI training workshops are built for exactly that rollout step.